Ovarian rejuvenation therapy is an advanced treatment designed to enhance fertility, often utilizing platelet-rich plasma (PRP) or stem cell therapy.
Stem cell ovarian rejuvenation, also known as Autologous Stem Cell Transplant in the Ovary (ASCOT), involves using undifferentiated stem cells that can develop into various types of cells, including ovarian cells. This therapy aims to assist women with fertility issues such as premature ovarian failure, low ovarian reserve, or cancer-related infertility.
Ovarian rejuvenation is a procedure that helps women experiencing fertility challenges due to age or medical conditions. The treatment stimulates the ovaries to produce healthier and more abundant eggs, potentially increasing the chances of conception and pregnancy.
The main goal of ovarian rejuvenation is to enhance the quality and quantity of a woman's eggs, which may improve fertility. It may also delay menopause and alleviate symptoms associated with ovarian aging. This therapy is intended to enable women to conceive using their own eggs.
The process of stem cell ovarian therapy and PRP therapy generally involves the following steps:
1. Consultation & Evaluation: A thorough consultation with a fertility specialist is the first step, involving a review of medical history, discussion of fertility goals, and possibly some diagnostic tests.
2. Extraction:
For PRP therapy, blood is drawn from the patient and processed to prepare Platelet-Rich Plasma (PRP).
In stem cell therapy, stem cells are extracted from sources like bone marrow or adipose tissue, typically under anesthesia.
3. Preparation:
PRP therapy involves processing the extracted blood in a centrifuge to isolate the platelets and plasma.
In stem cell therapy, the extracted stem cells are prepared for transplantation. Some methods involve fragmenting the ovarian cortex into small pieces.
4. Transplantation:
In PRP therapy, the prepared PRP is injected directly into the ovaries.
In stem cell therapy, stem cells are injected into the ovary using a laparoscopic technique. A specialized needle is used, and the process requires precise angulation. Bone marrow aspiration is performed by an orthopaedic surgeon, focusing on the theca stem cells present in the ovary. However, research is ongoing regarding the optimal extraction and culture of these stem cells.
5. Post-Procedure Care: Patients are closely monitored after the procedure to assess effectiveness and manage any potential side effects.
6. Follow-up & Monitoring: Regular follow-ups are crucial to monitor menstrual patterns, hormone levels, and signs of improved ovarian function.
Risks and Complications
While ovarian rejuvenation therapy is promising, it is still experimental and may not be suitable for everyone. Potential risks include:
• Minimal risk of miscarriage, particularly if performed before 15 weeks of pregnancy.
• Rare needle injuries or complications.
• Cramping, mild vaginal bleeding, or amniotic fluid leakage.
• Potential for uterine infections.
• Rh incompatibility if fetal blood cells enter the mother’s bloodstream.
Chorionic villus sampling (CVS) is an alternative, typically performed between 11-14 weeks of pregnancy, and offers similar accuracy. Non-invasive tests, such as second-trimester blood tests or free fetal DNA testing, are safer options but may not be as definitive.
Preparation includes discussing allergies, medications, and medical history with the doctor. No specific dietary restrictions are necessary, but maintaining a healthy diet is advised. Consult your doctor about any blood-thinning medications or bleeding disorders. It is generally recommended to have an empty bladder before the procedure.
Ovarian rejuvenation therapy has an approximate accuracy rate of 99.4%. However, rare technical issues may affect results, such as insufficient fluid collection.
Recovery After Ovarian Rejuvenation
Post-procedure, some cramping or mild discomfort is normal. Patients may be monitored for up to 24 hours and should rest and avoid strenuous activities. Immediate medical attention is required if symptoms such as heavy bleeding, fever, severe pain, or changes in fetal activity occur.
The success rate for stem cell therapy in ovarian rejuvenation is estimated at 15-20%, though individual outcomes can vary. Comprehensive clinical trials are needed to confirm effectiveness.
Selecting a fertility clinic for ovarian rejuvenation therapy is crucial. Consider factors such as the clinic's approach to treatment, the experience of its team, and the quality of patient care. Consult with a fertility specialist to discuss the risks, costs, and benefits of the therapy.
If you are considering ovarian rejuvenation therapy, it's important to consult a qualified fertility specialist to assess your suitability and explore all available options.
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